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RESEARCH ARTICLE
Year : 2015  |  Volume : 14  |  Issue : 1  |  Page : 40-45

Evaluation of lipid profile and lipid peroxidase level in pregnant women with pregnancy induce hypertension, preeclampsia and eclampsia in their third trimester of pregnancy versus normotensive pregnant women in the same trimester



Correspondence Address:
Esraa H AL-Maini
Assis. Prof. College of Medicine/Al-Mustansiriya University/Consultant Obs. & Al-Yarmouk Teaching Hospital

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Source of Support: None, Conflict of Interest: None


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Background: The association of altered lipid profile in essential hypertension is well documented. The pathophysiology of the underlying mechanism is unknown. Disorder of lipoprotein metabolism may contribute to endothelial dysfunction. Oxidative stress and decreased antioxidant defense enhance free radical-mediated membrane lipid peroxidation and possibly vascular endothelial damage. Objective: To assess the relationship between lipid level and lipid peroxidase with occurrence of hypertension in pregnant women in their third trimester of pregnancy. Study design: Case control study. Patient and Method: A total of one hundred twenty five pregnant women in their third trimester of pregnancy were enrolled in this study. Fifty normotensive pregnant women, thirty pregnant women with pregnancy induce hypertension (PIH), thirty pregnant women with preeclampsia and fifteen pregnant women with eclampsia. The four group were comparable for maternal age, body mass index and gestational age. Blood samples were taken for measurement of serum lipid and lipid peroxidase from the four groups and correlate with occurrence of pregnancy induce hypertension, preeclampsia and eclampsia. Result: There was a significant and direct correlation between occurrence of preeclampsia and total cholesterol in comparison to the control group. There was a significant and direct correlation between preeclampsia and triglyceride, high density lipoprotein, low density lipoprotein /cholesterol level. There was a significant correlation between malondialdehyde level and preeclampsia in comparison to the control group. Also there is recognized relation between the malondialdehyde level and eclampsia. Conclusion: abnormal lipid metabolism may play a role in the development of preeclampsia and eclampsia, can be used as a measure for early prediction of this disorder.


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