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RESEARCH ARTICLE
Year : 2015  |  Volume : 14  |  Issue : 2  |  Page : 11-16

Serum profile of cytokines in Iraqi inflammatory bowel disease patients


1 Department of Biology, College of Education Ibn Al-Hitham, University of Baghdad, Baghdad, Iraq
2 Department of Biology, College of Science, University of Diyala, Baghdad, Iraq
3 Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq

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Source of Support: None, Conflict of Interest: None


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Background: Studies indicated that IBD-related tissue damage results from a dynamic interplay between immune and non-immune cells, in which cytokines are crucial mediators. Aim: To determine serum level of eight cytokines (IL-2, IL-4, IL-8, IL-10, IL-12, IL-17A, IP-10 and IFN-γ) in inflammatory bowel disease (IBD) Iraqi patients. Patients and Methods: The IBD patients (54 ulcerative colitis; UC and 25 Crohn's disease; CD) attended the Gastrointestinal Teaching Hospital in Baghdad for diagnosis and treatment during the period March-August 2012. Serum level of cytokines was determined by ELISA method. Results: Four cytokines showed significant variations between UC patients and controls. Levels of IL-8 (2.47 ± 0.35 vs. 0.48 ± 0.19 pg/ml), IL-12 (5.06 ± 0.47 vs. 1.58 ± 0.79 pg/ml) and IP-10 (6.96 ± 1.02 vs. 1.98 ± 0.76 pg/ml) were increased in patients, while level of IL-10 (2.72 ± 0.44 vs. 7.33 ± 2.32 pg/ml) was decreased. In CD patients, levels of IL-8 (3.26 ± 0.56 vs. 0.48 ± 0.19 pg/ml), IL-12 (4.71 ± 0.79 vs. 1.58 ± 0.79 pg/ml) and IP-10 (5.03 ± 1.50 vs. 1.98 ± 0.76 pg/ml) were also significantly increased in patients compared to controls. Comparing UC and CD patients revealed that IL-10 level was significantly decreased in UC patients (2.72 ± 0.44 vs. 5.79 ± 1.10 pg/ml), while IFN-γ was significantly increased (5.99 ± 0.49 vs. 3.78 ± 0.61 pg/ml). Conclusion: These findings highlight a pathogenic role of these cytokines in UC and CD patients.


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