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Year : 2015  |  Volume : 14  |  Issue : 2  |  Page : 17-21

The cytokine genetic polymorphism of interleukin-10 and interleukin-12 in systemic lupus erythematosus disease

1 Tropical-Biological Research Unit, College of Science/ University of Baghdad, Iraq
2 Department of biology, College of Science for Women/ University of Baghdad, Iraq

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Source of Support: None, Conflict of Interest: None

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Background: Systemic lupus erythematosus is a systemic autoimmune disease or autoimmune connective tissue disease in which the body's immune system incorrectly attacks healthy tissue. Cytokine imbalance has been demonstrated in systemic lupus erythematosus patients. Objective: The aim of this study was to clarify the cytokine genetic polymorphisms of interleukin-10, interlukin-12, and systemic lupus erythematosus. Patients and Methods: This study was conducted in Medical City Hospital through the period from June 2013 until the end of October 2014. Fourty six female patients with systemic lupus erythematous were enrolled in this study; their age range was (18-45) years and they were compared with 44 healthy controls. About 5 ml of blood sample was obtained from every systemic lupus erythematosus patient and control. The separated serum was used for measurements of interleukin-10, interleukin-12, and cytokine genetic polymorphism. Results: Interleukin-10 and interlukin-12 showed a significant increased level in patients as compared to the controls (P ≤ 0.001). Genetic polymorphisms of tow cytokine genes (interleukin-10 and interleukin-12) at 4 positions (interleukin 10-1082, interleukin 10-819, interleukin 10-592 and interleukin 12-1188) were determined in patients and the control. Conclusions: It can be concluded that serum interleukin-10 and interleukin-12 was increased in patients as compared to the control group, so the declining its concentration would help prevention of systemic lupus erythematosus disease.

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