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Year : 2015  |  Volume : 14  |  Issue : 2  |  Page : 22-27

The prevalence of clinical, subclinical hypothyroidism and autoimmune thyroiditis in patients with polycystic ovarian syndrome

1 College of Medicine - Al Mustansiriya University
2 National Diabetic Center - Al Mustansiriya University

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Background: Abnormal thyroid function test is generally associated with polycystic ovarian syndrome (PCOS). Objective: To detect the prevalence of hypothyroidism modalities in patients with PCOS and to evaluate the role of thyroid hormone changes in association with PCOS. Study design and setting: A cross sectional study carried out at the Department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital for a period of one year from January 2013 to January 2014. Patients and Methods: One hundred females with polycystic ovarian syndrome were taken. From each patient, blood sample was taken for thyroid function test (triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH)), anti-thyroid antibodies (anti-thyroid peroxidase antibodies (anti TPO)) and anti-thyroglobulin antibodies (anti-TG). Results: The current study revealed that the prevalence of thyroid dysfunction in the participant females with PCOS was 29% (9% had subclinical hypothyroidism, 5% had clinical hypothyroidism and 15% had autoimmune thyroiditis). Thyroid stimulating hormone had shown to be significantly higher (p<0.001) among the PCOS female group with thyroid dysfunction (being the highest in clinical hypothyroid, while it's increased level shows no significant difference between the subclinical hypothyroid group and autoimmune thyroiditis group) as compared to euthyroid females with PCOS. Higher levels of thyroid auto-antibodies were present in the sera of PCOS patients diagnosed with autoimmune thyroiditis (46.7%). Conclusion: The current study showed that clinical, subclinical hypothyroidism and autoimmune thyroiditis were found in a significant number of patients with polycystic ovarian syndrome. We recommend assessment of the thyroid function routinely in patients with PCOS and offer thyroid hormone replacement therapy if necessary.

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