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RESEARCH ARTICLE
Year : 2016  |  Volume : 15  |  Issue : 1  |  Page : 84-87

Evaluation of serum Interleukin-6, body mass index and bone mineral density in patients with nodal osteoarthritis



Correspondence Address:
Abbas Toma Joda
Lecturer in Department of Internal Medicine/, College of Medicine, Al-Mustansiryia University

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Source of Support: None, Conflict of Interest: None


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Background: Nodal osteoarthritis is a type of osteoarthritis and its common worldwide, the etiology is unknown but there are a biochemical markers recognized. Many studies have explain that adiponectin have an important role in the pathogenesis of osteoarthritis, but little is studied about the relation between serum Interleukin-6, body mass index and bone minerals density with nodal osteoarthritis. Objectives: To evaluate serum level of Interleukin-6, body mass index and bone minerals density in nodal osteoarthritis patients. Methods: Sixty patients with nodal osteoarthritis and sixty controls were included in the study; serum Interleukin-6, body mass index and bone mineral density were measured in all subjects. Student t-test was applied to find out the significant difference between two means. Result: This study shows a significant increase in body mass index (BMI) in those patients with nodal osteoarthritis (mean + SD) (31.6 + 8.7), P-value < 0.05. the mean of serum IL-6 is significantly increased in patients (mean + SD) (3.2 + 2.2) P-value < 0.05. but not in control group and there's an obvious decrease in the bone mineral density between nodal osteoarthritis patients and control group (mean + SD)(-2.2+ -1.1) P-value < 0.05. Conclusion: This study shows the role of Interleukin-6 as inflammatory mediator in nodal osteoarthritis and osteoporosis. The BMI has a role in Interleukin-6 level and it's increased in nodal osteoarthritis patients.


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