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RESEARCH ARTICLE
Year : 2017  |  Volume : 16  |  Issue : 2  |  Page : 74-78

Matrix metalloproteinase – 9 expressions associated with malignant colorectal carcinoma


Department of Microbiology /College of medicine, Al-Mustansiriyah University, Baghdad, Iraq

Correspondence Address:
Zainab Fadhel Ashoor
Department of Microbiology /College of medicine, Al-Mustansiriyah University, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


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Cancer metastatic is dependent on capability of tumor cells to enter “blood and lymphatic system” and there after form tumors in “lymph nodes and distant organs”. Matrix metalloproteinase-9 (MMP-9) is considered to as important for degradation of the basement membrane and extracellular matrix through cancer invasion and other tissue-remodelling events. This study evaluate the value of Matrix metalloproteinase-9, by Immunohistochemical technique in a series of 50 colorectal carcinoma tissues. There was a significant difference betweenMMP-9protein and tumor differentiation, as well as tumor stage. There was highly significant difference in mean percentage of (MMP-9) proteins expression in tissue of colorectal carcinoma (CRC) and colorectal normal tissue (CRN). Conclusion: This study shows that (MMP-9) expression in colorectal cancer is related with better prognosis.


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