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ORIGINAL ARTICLE
Year : 2018  |  Volume : 17  |  Issue : 2  |  Page : 80-84

Serum irisin levels in normotensive and preeclamptic pregnancies


1 Department of Obstetrics and Gynaecology, College of Medicine, Al-Mustansiriyah University, Al-Yarmouk Teaching Hospital, Baghdad, Iraq
2 Department of Obstetrics and Gynaecology, College of Medicine, Al-Mustansiriyah University, Baghdad, Iraq

Correspondence Address:
Dr. Fatin Shallal Farhan
Department of Obstetrics and Gynaecology, College of Medicine, Al-Mustansiriyah University, Al-Yarmouk Teaching Hospital, Baghdad
Iraq
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/MJ.MJ_22_18

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Background: Early prediction of preeclampsia represents a big dilemma for obstetricians, but the discovery of a novel biomarker highlights the way for its prediction during the early stage of the pregnancy. Objective: The objective of this study was to evaluate serum irisin levels in preeclamptic and healthy pregnant women in the third trimester of pregnancy. Materials and Methods: This study was a prospective case–control study conducted at Al-Yarmouk Teaching Hospital during the period from October 1, 2017, to May 1, 2018. Totally 80 pregnant women were enrolled in the study; 40 of them were preeclamptic patients and the other 40 were healthy pregnant women assigned as a control group. Serum irisin levels were measured to all participants by enzyme-linked immunosorbent assay method. The results were compared for both groups. Results: Serum irisin was lower in preeclamptic patients compared to controls (280.7 vs. 311.3 μg/L, respectively), but the difference was not statistically significant as the P value was 0.189. Conclusion: Irisin might be involved as a biomarker for pregnancy-associated problems such as preeclampsia.


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