• Users Online: 57
  • Print this page
  • Email this page

Table of Contents
Year : 2019  |  Volume : 18  |  Issue : 1  |  Page : 51-53

Metachronous cancer of the nasal cavity after totally cured larynx squamous cell carcinoma

1 Department of ENT, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey
2 Department of ENT, Etimesgut State Hospital, Ankara, Turkey

Date of Web Publication10-May-2019

Correspondence Address:
Mehmet Gökhan Demir
Umit Mah. Meksika Cad. Defne 9 Sit. No: 1/21 Cankaya, Ankara
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MJ.MJ_31_18

Rights and Permissions

Head-and-neck region tumors are mostly seen on the larynx. The risk factors of this region may increase the secondary tumors. Nasal squamous cell carcinoma (SCC) can be detected after larynx SCCs, a second primary tumor. Second primary tumors are difficult to manage. Total rhinectomy is the choice of treatment modality, but rehabilitation is necessary. We present a secondary nasal SCC treated with total rhinectomy. A 67-year-old patient, who was treated for larynx SCC by total laryngectomy 3 years ago, was admitted to the outpatient clinic with a complaint of nasal swelling and pain. The patient was diagnosed as nasal SCC. Total rhinectomy was performed, and silicon nasal prosthesis was applied after 3 months of surgery. Total rhinectomy can be rehabilitated via silicon nasal prosthesis. This was cost-effective, safe, less time-consuming, and functional. Using prosthesis has given us better chance to detect recurrences. We encourage surgeons to use prosthesis for rehabilitation.

Keywords: Metachronous tumors, nasal squamous cell carcinoma, rhinectomy, silicon nasal prosthesis

How to cite this article:
Aydin S, Demir MG, Dikmen B, Paksoy M, Çakil T, Çoruk S. Metachronous cancer of the nasal cavity after totally cured larynx squamous cell carcinoma. Mustansiriya Med J 2019;18:51-3

How to cite this URL:
Aydin S, Demir MG, Dikmen B, Paksoy M, Çakil T, Çoruk S. Metachronous cancer of the nasal cavity after totally cured larynx squamous cell carcinoma. Mustansiriya Med J [serial online] 2019 [cited 2023 Feb 1];18:51-3. Available from: https://www.mmjonweb.org/text.asp?2019/18/1/51/257906

  Introduction Top

The presence of second primary cancers is a challenging situation for cancer treatment. It is known that after new innovations in radiological screening instruments, the second primary cancer rate is approximately 5%.[1] Predisposing factors such as tobacco usage and alcohol consumption are related to both primary and secondary cancers, especially in the head-and-neck region. It has been known that larynx cancers are the most common cancer in the head-and-neck region.[1] Advances in cancer treatment might supply the long-term survival rates, but still we have not known the results. There are many factors affecting the survival rates such as second primary tumors. Warren and Gates specify the secondary primary tumors as the histologically identifiable tumor, topographically distinct and separate from the primary tumor, and ruling out from the metastasis of the primary tumor.[2] Classification is specified depending on the time of the diagnosis of the secondary tumor. Synchronous tumors are diagnosed either at the same time or within a 6-month period from the primary tumor. Metachronous tumors are diagnosed at least 6 months after primary diagnosis.[2]

  Case Report Top

A 67-year-old male patient was diagnosed with larynx squamous cell carcinoma (SCC) and treated with total laryngectomy before 3 years. The disease was in remission, but on follow-up, the patient complained with nasal tenderness over the nasal vestibule and purulent nasal drainage. He was treated by antibiotic therapy, but the tenderness was not healed and contrastingly the clinical status worsened, so he was referred to our clinic. Physical examination revealed an ulcerovegetan mass lesion on the vestibule of the nose which was extended posteriorly and obliterated the nasal cavity bilaterally [Figure 1]a and [Figure 1]b. There was no sign of neck metastasis. Magnetic resonance investigation revealed lobulated, contrast-enhanced, 24 mm × 18 mm-diameter mass lesion on the anterior side of the nasal vestibule and confirmed the absence of neck metastasis [Figure 2]. After completing the imaging investigation, biopsy from the mass was taken and the tumor was diagnosed as SCC of the nasal vestibule. Total rhinectomy was planned to perform under general anesthesia. After marking the surgical site completely, incisional lines of bilateral lateral rhinotomy were marked and infiltration anesthesia was performed. The incision was started from the lateral edge of the nostrils with 1.5-cm clear margins and then carried through the dorsum of the nose and joined with inferior skin incision. The dissection was started from the lateral edge and lateral cartilages were separated from the bony structures. Then, the base of the columella was incised and caudal septum was visualized. Osteotomies were performed on both sides. The tumor was excised with clear margins. Frozen section was sent to pathology (the nasal SCC stage is T4N0M0, previous larynx SCC stage is T3N0M0) to determine the clear surgical margins. Mucosal bleeding was controlled by electrocautery. The skin defect and mucosa were sutured primarily. Epithesis was implanted to frontonasal process bilaterally and the remaining nasal bone on the midline. Two months after rhinotomy, nasal silicon prosthesis was applied for reconstruction [Figure 3]a and [Figure 3]b. On follow-up, there is no recurrence or any complaint.
Figure 1: (a) Preoperative frontal view of the ulserovegetan mass lesion of the nose. (b) Preoperative lateral view of the ulserovegetan mass lesion of the nose

Click here to view
Figure 2: Magnetic resonance image of the nasal squamous cell carcinoma

Click here to view
Figure 3: (a) Frontal view of the total rhinectomy defect and silicon prosthesis application. (b) Lateral view of the total rhinectomy defect and application of the silicon nasal prosthesis

Click here to view

  Discussion Top

Larynx cancers are the most common cancer in the head-and-neck region. Most of the tumors are SCC.[3] The treatment modalities depend on the stage and medical status of the patient and mainly are surgery, radiotherapy, chemotherapy, or combination of them. Advanced larynx cancers can be treated via total laryngectomy, same as our case. Malignancies of the nasal cavity and paranasal sinuses encompass only 3% of the head-and-neck region and 50% of the cases are SCC.[4],[5],[6] Second primary nasal cavity SCC is extremely rare as it is known. The behavior of the cancer in this region is local aggressiveness and tendency to rapid spread. Disease control is supplied via local wide excision. Overall, 10%–14% of the larynx cancers are expected to develop second primary neoplasm and 10% of the cancers are synchronous.[7] Boysen and Loven reported the yearly incidence of the second primary cancer as 2.1% after larynx cancer.[8] Another study that investigated 514 patients concluded the second primary cancer rate as 8.17%, of which 1.55% are synchronous and 6.61% are metachronous.[9] The most common second primary cancer is lung cancer followed by esophagus and urinary bladder cancers, but nasal cavity cancers are extremely rare.[10] It is obvious that second primary cancers are difficult to manage even when diagnosed at a very early stage.[9]

Previously reported most common symptoms were epistaxis and nasal swelling. In our case, the patient had both tenderness and swelling. The diagnosis can be done by biopsy, but the average time for diagnosis was 5.7 months.[11] The time is related with nonspecific symptoms of the tumor. In our case, the patient was treated with antibiotics due to a suspicion of infection, but even after treatment, the symptoms were not recovered. The treatment method is complete excision of the tumor by total rhinectomy, but posttotal rhinectomy is an important aspect of the treatment. There are two options to supply the appearance: one is the otologous flap reconstruction and the other is the application of the nasal prosthesis.[12],[13] Osseointegrated abutment can be placed during rhinectomy and after 3 months, the silicon prosthesis can be applied by this way. In our case, the treatment modality is total rhinectomy to supply the disease-free margins. During the operation, we applied the abutments for implantation of the silicon prosthesis.

Surgical repair of the total rhinectomy is a complex reconstruction involving three-layer repair. More than three surgeries might be necessary which might result with lots of complications and ignorance of the disease recurrence.[12],[13] A previous study performed on 51 patients showed that limited resection of the SCC resulted with recurrence of the tumor.[14] If there is a surgical correction of the defect after total rhinectomy, the recurrence of the tumor might be missed. Most of the recurrences are detected within 1 year. Nasal ala, medial canthus, and columella are the most common sites of recurrence.[15] Local and forehead flaps might prevent the diagnosis of recurrence. We believed that reconstruction of rhinectomy is a dangerous way to detect recurrences. Recurrences under the flaps might be ignored and at the end, if there is a recurrence, both flaps and recurrence excision cause huge defects. Benech et al. reported an 80-year-old previously laryngectomized patient who was diagnosed with nasal SCC. He was treated via forehead flap multistep surgery after total rhinectomy, but on follow-up, SCC recurred and wide local excision involving the flap was performed. Then, they used a silicon prosthesis as reconstruction.[16]

After total rhinectomy, patients deal with negative self-esteem and social isolation.[8] The advantageous part of the nasal prosthesis is the inspection of the former tumor region and taking biopsy easily.[17],[18] Low-cost early rehabilitation and short operation time are the other beneficial components of the prosthesis. Psychological problems due to total rhinectomy are shown in previous reports.[18],[19] Hence, all patients should be evaluated during the surgical process and follow-up. Our patient also was consulted before surgery. He was mildly depressed due to foul smelling of the tumor in the nose. This smell also disturbs the other patients, so we must isolate the patient in a single room. After surgery, the patient was happy due to improvement of the smell, but the appearance of the face disturbed him this time. He was deeply depressed after surgery due to appearance, but when we applied the prosthesis, he was feeling good again. Early prosthetic application might be important for controlling cancer and clinicians might easily check patient for recurrence of the disease.

Becker et al. investigated 43 total rhinectomy patients who were rehabilitated via nasal prosthesis. They have concluded that overall functional appearance and fit of the nasal prosthesis were acceptable for users.[11] The results of the nasal appearance were the same as that of nasal surgical reconstruction after total rhinectomy.[20],[21] If the prosthesis is a bone-anchored or implant-retained facial prosthesis, the stability of the prosthesis is acceptable and does not disturb daily activities such as housekeeping and sports.[8] The cleaning problem is not mentioned from any users, but renewal of the prosthesis is necessary about every 2 years.[11] In addition, Becker et al. emphasized the change of the professional career of the total rhinectomy patients as difficult work situation or early retirement.[11]

  Conclusion Top

Larynx SCC with metachronous secondary primary nasal SCC is an extremely rare status, and few reports have been seen in literature. To our knowledge, both total laryngectomy and rhinectomy and rehabilitation with nasal silicon prosthesis on the same patient is presented in this case report firstly in the literature. We have emphasized that early rehabilitation with nasal prosthesis is a good way of psychological wellness and disease follow-up.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Steele GD, Winchester DP, MEnck HR, Murphy CP. Clinical highlights from the National Cancer Database. CA Cancer J Clin 1993;43:71-82.  Back to cited text no. 1
Warren S, Gates O. Multiple primary malignant tumors: A survey of the literature and statistical study. Am J Cancer 1932;16:1358-414.  Back to cited text no. 2
Kennaway EL, Kennaway NM. A further study of the incidence of cancer of the lung and larynx. Br J Cancer 1947;1:260-98.  Back to cited text no. 3
Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and paranasal sinus carcinoma: Are we making progress? A series of 220 patients and a systematic review. Cancer 2001;92:3012-29.  Back to cited text no. 4
Thorup C, Sebbesen L, Danø H, Leetmaa M, Andersen M, Buchwald C, et al. Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004. Acta Oncol 2010;49:389-94.  Back to cited text no. 5
Ang KK, Harris J, Wheeler R, Weber R, Rosenthal DI, Nguyen-Tân PF, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363:24-35.  Back to cited text no. 6
Johnson JT. Carcinoma of the larynx: Selective approach to the management of cervical lymphatics. Ear Nose Throat J 1994;73:303-5.  Back to cited text no. 7
Boysen M, Loven JO. Second malignant neoplasms in patients with head and neck squamous cell carcinomas. Acta Oncol 1993;32:283-8.  Back to cited text no. 8
Nikolaou AC, Markou CD, Petridis DG, Daniilidis IC. Second primary neoplasms in patients with laryngeal carcinoma. Laryngoscope 2000;110:58-64.  Back to cited text no. 9
Howel D. Correspondence re: Neugut AI, et al., differences in histology between first and second primary lung cancer. Cancer epidemiol., biomarkers and prev., 1: 109-112, 1992. Cancer Epidemiol Biomarkers Prev 1992;1:423-4.  Back to cited text no. 10
Becker C, Kayser G, Pfeiffer J. Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment. Head Neck 2016;38 Suppl 1:E2112-7.  Back to cited text no. 11
Miller TA. Nasal reconstruction. Surg Clin North Am 1986;66:189-200.  Back to cited text no. 12
Mendelson BC, Masson JK, Arnold PG, Erich JB. Flaps used for nasal reconstruction: A perspective based on 180 cases. Mayo Clin Proc 1979;54:91-6.  Back to cited text no. 13
Stanley RJ, Olsen KD. Rhinectomy for malignant disease. A 20-year experience. Arch Otolaryngol Head Neck Surg 1988;114:1307-11.  Back to cited text no. 14
Mignogna FV, Garay KF. Surgical rescue of recurrent carcinoma of the nasal columella. Am J Surg 1995;170:453-6.  Back to cited text no. 15
Benech A, Arcuri F, Nicolotti M, Crespi MC, Pia F. Total nasal prosthesis after resection of a recurrence of skin carcinoma on a forehead flap in a post-rhinectomy site. J Craniofac Surg 2012;23:e627-8.  Back to cited text no. 16
DiLeo MD, Miller RH, Rice JC, Butcher RB. Nasal septal squamous cell carcinoma: A chart review and meta-analysis. Laryngoscope 1996;106:1218-22.  Back to cited text no. 17
Brantsch KD, Meisner C, Schönfisch B, Trilling B, Wehner-Caroli J, Röcken M, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: A prospective study. Lancet Oncol 2008;9:713-20.  Back to cited text no. 18
Atay A, Peker K, Günay Y, Ebrinç S, Karayazgan B, Uysal Ö, et al. Assessment of health-related quality of life in Turkish patients with facial prostheses. Health Qual Life Outcomes 2013;11:11.  Back to cited text no. 19
Brenner P, Berger A. Epitheses of the face. Handchir Mikrochir Plast Chir 1992;24:88-92.  Back to cited text no. 20
Moolenburgh SE, Mureau MA, Hofer SO. Aesthetic outcome after nasal reconstruction: Patient versus panel perception. J Plast Reconstr Aesthet Surg 2008;61:1459-64.  Back to cited text no. 21


  [Figure 1], [Figure 2], [Figure 3]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
Case Report
Article Figures

 Article Access Statistics
    PDF Downloaded237    
    Comments [Add]    

Recommend this journal